Naltrexone Weight Loss

Natrexone has historically been used for opioid and alcohol addiction. This is at dose of 50mg or so. The question we were asked are going to answer is: Does Naltexone work for weight loss? 

If you don't know what (LDN) Low Dose Naltrexone you can read this article, by clicking here

In this article, I'll dive into the use of naltrexone for weight loss, discussing how it works, its potential benefits and risks, and current research on its effectiveness. Whether you’re looking for a new approach to weight loss or simply curious about this emerging treatment option, read on to learn more.

So how does it work?

Current science believes that it works in our brain and on hour hormones.

It is believed that naltrexone has an effect on the area of the brain involved with regulating appetite. Naltrexone works by binding to opioid receptors in the brain, which may decrease the release of dopamine. Dopamine is a neurotransmitter involved in feelings of pleasure, reward, and motivation. It is thought that by decreasing the release of dopamine, naltrexone may reduce the desire to overeat. Furthermore, it could be effective in helping with anxiety or depression.

Taking naltrexone may reduce a persons' appetite and lead a person to eat less.  Naltrexone may do this by affecting the release of certain hormones that play a role in appetite and metabolism, such as ghrelin and leptin. Ghrelin stimulates appetite and promotes weight gain, leptin suppresses appetite. Ghrelin and leptin work together to regulate metabolism and appetite. 

Benefits and risks

Depending on the dose, naltrexone has been shown to reduce weight by 4-8 pounds per month. When combined with other medications like Wellbutrin it can cause even more weight loss. The dose required with Wellbutrin is lower than the dose shown to cause an 8 pound weight loss.

There are some side effects to using naltrexone so it is important to talk to your pharmacist about these as they can be minimized or avoided. 

Is it safe and effective:  

Yes according to this article on the NIH's website.  In meta analysis and in over 10 clinical studies,  the combination of wellbutrin and naltrexone is safe and effective. 

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