What Are Estriol Suppositories?
Estriol suppositories are a bioidentical hormone therapy designed to support women's health by providing localized estrogen support. Estriol, a naturally occurring estrogen, plays a crucial role in maintaining vaginal and urinary tract health, promoting hormonal balance, and enhancing overall well-being.
Benefits of Estriol Suppositories
- Supports Vaginal Health: Helps relieve vaginal dryness, irritation, and discomfort often associated with menopause or hormonal imbalances.
- Improves Urinary Tract Function: May reduce the risk of urinary tract infections and support bladder health.
- Restores Hormonal Balance: Aids in replenishing estrogen levels for optimal health and comfort.
- Localized and Effective: Delivers estriol directly to the affected area for targeted relief.
How to Use
Estriol suppositories are typically inserted vaginally once daily or as prescribed by your healthcare provider. Always follow the specific instructions provided with your prescription.
Why Choose Compounded Estriol Suppositories?
Unlike mass-produced hormone therapies, compounded estriol suppositories are customized to meet individual patient needs. Webster Pharmacy specializes in creating high-quality, personalized hormone therapy solutions tailored to your unique health requirements.
For more information or to place an order, contact Webster Pharmacy today!
Evidence supporting the use of estriol vaginal suppositories primarily focuses on their efficacy in treating vulvovaginal atrophy (VVA) and genitourinary syndrome of menopause (GSM), particularly in postmenopausal women. Below is a summary of key findings:
Clinical Studies
- Estriol Vaginal Cream vs. Suppositories:A study involving 30 postmenopausal women with vaginal atrophy compared estriol vaginal cream and suppositories containing 0.5 mg estriol. Both treatments resulted in subjective relief of vaginal symptoms and restoration of vaginal mucosa, confirmed by colposcopy. Hormonal variables showed no significant differences between the two preparations, and no endometrial stimulation was detected1.
- Ultra-Low Dose Estriol Gel:A phase II randomized trial assessed the efficacy of 0.005% estriol vaginal gel in postmenopausal women receiving nonsteroidal aromatase inhibitors for breast cancer treatment. The gel significantly improved vaginal maturation, pH, dryness, and global GSM symptoms without notable systemic hormonal changes, demonstrating safety and efficacy45.
- Systematic Review:A comprehensive review confirmed that vaginal estriol effectively alleviates GSM symptoms while having minimal impact on serum hormone levels, suggesting a favorable safety profile for localized treatment8.
Treatment Protocols
- Estriol suppositories are typically administered daily for several weeks, followed by maintenance doses twice weekly24. This regimen is effective in reversing VVA symptoms without systemic estrogenic effects.
Safety Profile
- Estriol is considered safer than stronger estrogens like estradiol due to its weaker estrogenic potential and preferential affinity for β (urogenital) estrogen receptors over α (breast) receptors. Studies have shown minimal systemic hormonal changes during treatment48.
Conclusion
Estriol vaginal suppositories are supported by clinical evidence as an effective and safe option for managing VVA and GSM symptoms in postmenopausal women, including those with contraindications to systemic estrogen therapy.
If you are interested in Estriol Suppositories, consult with your healthcare provider to determine if this treatment is right for you. Webster Pharmacy is here to help with expert compounding services designed for your specific health needs.
